Yeast and apoptosis

Nat Rev Mol Cell Biol. 2002 Jun;3(6):453-9. doi: 10.1038/nrm832.


Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis proteins in yeast can help us to discover new genes -- and chemical compounds -- that modulate the cell-death pathways of higher eukaryotes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics*
  • Mammals
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology
  • Schizosaccharomyces / genetics
  • Schizosaccharomyces / physiology
  • Yeasts / genetics
  • Yeasts / physiology*