Ganglioside reactive antibodies in the neuropathy associated with celiac disease

J Neuroimmunol. 2002 Jun;127(1-2):145-8. doi: 10.1016/s0165-5728(02)00102-9.


We tested patients with celiac disease (CD) for the presence of serum anti-ganglioside antibodies. Six of twenty-seven patient sera were reactive against brain gangliosides by an agglutination immunoassay. Neurological examination in all six revealed the presence of distal sensory loss, consistent with the diagnosis of peripheral neuropathy. When tested by ELISA for antibodies to isolated GM1, GM2, GD1a, GD1b, GT1b, and GQ1b gangliosides, all six were positive for IgG antibodies to at least one. The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / blood*
  • Celiac Disease / complications
  • Celiac Disease / immunology*
  • Female
  • Gangliosides / immunology*
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Male
  • Middle Aged
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / immunology*


  • Autoantibodies
  • Gangliosides
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M