Lipoprotein receptors in the nervous system

Annu Rev Biochem. 2002;71:405-34. doi: 10.1146/annurev.biochem.71.110601.135342. Epub 2001 Nov 9.

Abstract

The low-density-lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease activity. Some members of the family also participate in cellular signaling and regulate the development and functional maintenance of the nervous system. Here we review the roles of this family of multifunctional receptors in the nervous system and focus on recent advances toward the understanding of the mechanisms by which lipoprotein receptors and their ligands transmit and modulate signals in the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apolipoproteins E / genetics
  • Apolipoproteins E / metabolism
  • Brain / growth & development
  • Brain / physiology*
  • Caveolae / metabolism
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Central Nervous System / physiology*
  • Cholesterol / metabolism
  • Extracellular Matrix Proteins / metabolism
  • Hedgehog Proteins
  • Learning / physiology
  • Ligands
  • Membrane Microdomains / metabolism
  • Multigene Family
  • Nerve Tissue Proteins
  • Protein Transport / physiology
  • Proto-Oncogene Proteins / metabolism
  • Receptors, LDL / chemistry
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Serine Endopeptidases
  • Signal Transduction / physiology*
  • Trans-Activators / metabolism
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • Apolipoproteins E
  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Hedgehog Proteins
  • Ligands
  • Nerve Tissue Proteins
  • Proto-Oncogene Proteins
  • Receptors, LDL
  • Receptors, N-Methyl-D-Aspartate
  • Trans-Activators
  • Wnt Proteins
  • Zebrafish Proteins
  • Cholesterol
  • Serine Endopeptidases
  • reelin protein