Cytotoxic and apoptosis-inducing ent-kaurane-type diterpenoids from the Japanese liverwort Jungermannia truncata NEES

Chem Pharm Bull (Tokyo). 2002 Jun;50(6):808-13. doi: 10.1248/cpb.50.808.


Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.

MeSH terms

  • Apoptosis*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • HL-60 Cells
  • Humans
  • Japan
  • Molecular Conformation
  • Plants, Medicinal / chemistry*


  • Diterpenes