Field population-based blocking treatment of esophageal epithelia dysplasia

World J Gastroenterol. 2002 Jun;8(3):418-22. doi: 10.3748/wjg.v8.i3.418.


Aim: To confirm the value of blocking treatment by zenshengping (ZSP), a Chinese herb composite, and Riboflavin for esophageal epithelia dysplasia cases screened out in high risk area in northern china by exfoliative balloon cytology (EBC), so to reduce the incidence rate of esophageal cancer(EC).

Methods: Esophageal epithelium dysplasia cases including mind esophageal epithelium dysplasia (MEED), stage one severe esophageal epithelium dysplasia (SEED I), and stage two severe esophageal epithelium dysplasia (SEED II) were screened out from people aged 40 years and older in the high risk area of Chixian. These cases were randomly divided into a treatment and control group. Subjects in the treatment and control groups took ZSP, riboflavin, and placebo daily for three years. EC cases registered by cancer registry and identified by EBC re-screening in the treatment and control groups were used to calculate incidence and blocking rates to demonstrate the effects of blocking medication.

Results: It was found that 31.92% and 24.15% of people aged 40 years and older in Cixian could been diagnosed as MEED and SEED cases. The severity of dysplasia increased with age. ZSP had blocked EC occurrence by 47.79% after 3 year medication among the SEED cases.

Conclusion: ZSP can block the development from SEED I and SEED II to EC by 47.79%. Efforts should be made to screen and treat dysplasia cases in people aged 40 years and older in high risk areas to reduce the mortality figures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • China / epidemiology
  • Drugs, Chinese Herbal / therapeutic use*
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / prevention & control*
  • Esophagus / drug effects*
  • Esophagus / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy*
  • Precancerous Conditions / epidemiology
  • Precancerous Conditions / prevention & control


  • Drugs, Chinese Herbal