Genetic factors have been reported to play an important role in the predisposition to development of pregnancy-induced hypertension (PIH). On the other hand, there is strong evidence that genetic factors play important role in the predisposition to essential hypertension. Recently, the plausible "candidate gene" for the development of hypertension is SA gene. The aim of our study was to assess the association of the SA gene with the susceptibility to PIH. For that purpose, the SA gene A1A2 polymorphism was studied in 124 women (median age 28 yrs) suffering from PIH in comparison with 148 healthy pregnant women (median age 28 yrs). Genotyping was performed using methods based on polymerase chain reaction. In this study we found statistically significant more frequent of genotype A1A1 occurrence in the patients with PIH when compared to healthy pregnant controls. The frequency of A1 allele was also significant higher in PIH in comparison with controls (chi 2 test.) Based upon the results of our study we can suspect that the SA gene Pst1 polymorphism is associated with the predisposition to PIH in caucasian women.