Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench

Phytomedicine. 2002 Apr;9(3):249-53. doi: 10.1078/0944-7113-00105.

Abstract

Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 microg/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 microg/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 microg/ml.

MeSH terms

  • Aedes / drug effects
  • Amides / administration & dosage
  • Amides / pharmacology
  • Amides / therapeutic use
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Aspirin / pharmacology
  • Celecoxib
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors / administration & dosage
  • Cyclooxygenase Inhibitors / pharmacology*
  • Cyclooxygenase Inhibitors / therapeutic use
  • Dose-Response Relationship, Drug
  • Echinacea*
  • Ibuprofen / pharmacology
  • Isoenzymes / drug effects
  • Lactones / pharmacology
  • Lethal Dose 50
  • Naproxen / pharmacology
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Prostaglandin-Endoperoxide Synthases / drug effects
  • Pyrazoles
  • Sulfonamides / pharmacology
  • Sulfones

Substances

  • Amides
  • Anti-Inflammatory Agents
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Lactones
  • Plant Extracts
  • Pyrazoles
  • Sulfonamides
  • Sulfones
  • rofecoxib
  • Naproxen
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Celecoxib
  • Aspirin
  • Ibuprofen