Abstract
Alkamides from the roots of Echinacea purpurea (L.) Moench were examined for anti-inflammatory activity in an in vitro model system. Cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory activities were assessed at pH 7 for alkamides isolated from E. purpurea roots to compare inhibitory activities between the two cyclooxygenase isozymes. At 100 microg/ml, several E. purpurea alkamides inhibited COX-I and COX-II enzymes in the range of 36-60% and 15-46%, respectively, as compared to controls. Mosquitocidal activity was assessed at 100 and 10 microg/ml, with 100% mortality against Aedes aegyptii L. larvae noted for several E. purpurea alkamides at 100 microg/ml.
MeSH terms
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Aedes / drug effects
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Amides / administration & dosage
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Amides / pharmacology
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Amides / therapeutic use
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Aspirin / pharmacology
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Celecoxib
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / administration & dosage
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Cyclooxygenase Inhibitors / pharmacology*
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Cyclooxygenase Inhibitors / therapeutic use
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Dose-Response Relationship, Drug
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Echinacea*
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Ibuprofen / pharmacology
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Isoenzymes / drug effects
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Lactones / pharmacology
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Lethal Dose 50
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Naproxen / pharmacology
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots
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Prostaglandin-Endoperoxide Synthases / drug effects
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Pyrazoles
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Sulfonamides / pharmacology
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Sulfones
Substances
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Amides
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Anti-Inflammatory Agents
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Lactones
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Plant Extracts
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Pyrazoles
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Sulfonamides
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Sulfones
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rofecoxib
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Naproxen
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Cyclooxygenase 1
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Celecoxib
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Aspirin
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Ibuprofen