Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barré syndrome

Psychiatry Clin Neurosci. 2002 Jun;56(3):273-4. doi: 10.1046/j.1440-1819.2002.00974.x.


It is reported that cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain-Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin-1.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Carrier Proteins / cerebrospinal fluid*
  • Carrier Proteins / immunology
  • Female
  • Guillain-Barre Syndrome / cerebrospinal fluid*
  • Guillain-Barre Syndrome / immunology
  • HLA Antigens / immunology
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Multiple Sclerosis / cerebrospinal fluid
  • Neuropeptides / cerebrospinal fluid*
  • Neuropeptides / immunology
  • Orexins


  • Carrier Proteins
  • HCRT protein, human
  • HLA Antigens
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins