Mouse models of prostate carcinogenesis

Trends Genet. 2002 May;18(5):S1-5. doi: 10.1016/s0168-9525(02)02683-5.


In recent years, numerous mouse models have been generated that recapitulate salient features of prostate carcinogenesis in humans. Here we review progress in the generation and validation of mouse models for prostate cancer, discuss current limitations of these models, and highlight directions of future research.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Oncogenes
  • Prostatic Neoplasms / etiology*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / pathology
  • Simian virus 40 / genetics