Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum

Cancer Lett. 2002 Aug 28;182(2):155-61. doi: 10.1016/s0304-3835(02)00080-0.


The inhibitory effects of the dormant spores, the germinating spores, the sporoderm-broken germinating spores (SBGS), and the lipids extracted from the germinating spores of Ganoderma lucidum on the growth of mouse hepatoma, sarcoma S-180, and reticulocyte sarcoma L-II cells were investigated, respectively. The dormant spores could be activated by germination, and thus the bioactivities of the spores might be enhanced. The sporoderm-broken spores could show much higher bioactivities than the whole spores. Both the lipids extracted from the germinating spores and the SBGS of G. lucidum had remarkable antitumor effects in a dose-dependent manner, and could significantly inhibit three tumors with an inhibition of 80-90%.

MeSH terms

  • Administration, Oral
  • Animals
  • Antineoplastic Agents*
  • Disease Models, Animal
  • Liver Neoplasms, Experimental / drug therapy*
  • Liver Neoplasms, Experimental / pathology
  • Medicine, Chinese Traditional*
  • Mice
  • Reishi / physiology*
  • Sarcoma 180 / drug therapy*
  • Sarcoma, Experimental / drug therapy*
  • Spores, Fungal* / chemistry


  • Antineoplastic Agents