Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8366-71. doi: 10.1073/pnas.122210599. Epub 2002 Jun 4.


We investigated the role of A-type K(+) channels for the induction of long-term potentiation (LTP) of Schaffer collateral inputs to hippocampal CA1 pyramidal neurons. When low-amplitude excitatory postsynaptic potentials (EPSPs) were paired with two postsynaptic action potentials in a theta-burst pattern, N-methyl-d-aspartate (NMDA)-receptor-dependent LTP was induced. The amplitudes of the back-propagating action potentials were boosted in the dendrites only when they were coincident with the EPSPs. Mitogen-activated protein kinase (MAPK) inhibitors PD 098059 or U0126 shifted the activation of dendritic K(+) channels to more hyperpolarized potentials, reduced the boosting of dendritic action potentials by EPSPs, and suppressed the induction of LTP. These results support the hypothesis that dendritic K(+) channels and the boosting of back-propagating action potentials contribute to the induction of LTP in CA1 neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Butadienes / pharmacology
  • Computer Simulation
  • Dendrites / drug effects
  • Dendrites / physiology*
  • Enzyme Inhibitors / pharmacology
  • Excitatory Postsynaptic Potentials / drug effects
  • Excitatory Postsynaptic Potentials / physiology
  • Flavonoids / pharmacology
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Kinetics
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology*
  • MAP Kinase Signaling System / drug effects
  • MAP Kinase Signaling System / physiology
  • Neurons / drug effects
  • Neurons / physiology*
  • Nitriles / pharmacology
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology*
  • Rats
  • Rats, Sprague-Dawley


  • Butadienes
  • Enzyme Inhibitors
  • Flavonoids
  • Nitriles
  • Potassium Channels
  • U 0126
  • 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one