Synthesis and biological activity of hydroxamic acid-derived vasopeptidase inhibitor analogues

Andrew J Walz; Marvin J Miller

doi:10.1021/ol025896m

Synthesis and biological activity of hydroxamic acid-derived vasopeptidase inhibitor analogues

Org Lett. 2002 Jun 13;4(12):2047-50. doi: 10.1021/ol025896m.

Authors

Andrew J Walz¹, Marvin J Miller

Affiliation

¹ Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, USA.

PMID: 12049514
DOI: 10.1021/ol025896m

Abstract

[structure: see text] Syntheses of novel hydroxamic acid-derived azepinones containing pendant mercaptoacyl groups or formyl hydroxamates are described. These new analogues of therapeutically important ACE and NEP inhibitors include unprecedented changes at the previously assumed essential acid component.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Humans
Hydroxamic Acids / chemistry*
Peptide Hydrolases / drug effects*
Protease Inhibitors / chemical synthesis*
Protease Inhibitors / pharmacology*
Rabbits

Substances

Hydroxamic Acids
Protease Inhibitors
Peptide Hydrolases