Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis

Jason A Smulik; Steven T Diver; Fan Pan; Jun O Liu

doi:10.1021/ol0258987

Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis

Org Lett. 2002 Jun 13;4(12):2051-4. doi: 10.1021/ol0258987.

Authors

Jason A Smulik¹, Steven T Diver, Fan Pan, Jun O Liu

Affiliation

¹ Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

PMID: 12049515
DOI: 10.1021/ol0258987

Abstract

[reaction: see text] New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Affinity Labels / chemical synthesis*
Alkenes / chemistry*
Cyclosporine / chemistry*
Electrophoresis, Polyacrylamide Gel
Immunosuppressive Agents / chemistry*

Substances

Affinity Labels
Alkenes
Immunosuppressive Agents
Cyclosporine

Abstract

Publication types

MeSH terms

Substances

Grants and funding