XSPR-1 and XSPR-2, novel Sp1 related zinc finger containing genes, are dynamically expressed during Xenopus embryogenesis

Mech Dev. 2002 Jul;115(1-2):117-22. doi: 10.1016/s0925-4773(02)00086-2.


Proteins related to the human transcription factor Sp1 are characterized by the presence of a highly conserved zinc finger domain consisting of three C2H2 type zinc fingers. Here we describe two Xenopus laevis cDNAs, which encode novel Sp1-related C2H2 type zinc finger transcription factors named XSPR-1 and XSPR-2. Structurally, XSPR-1 and XSPR-2 are closely related to the murine Sp5, which interacts genetically with Brachyury (Dev. Biol. 227 (2000) 358). XSPR-1 and XSPR-2 are expressed in broad and dynamic patterns during early development. Starting at gastrulation, XSPR-1 transcripts are restricted to the non-involuting marginal zone, and, at later stages, to the neuroectoderm, forebrain, otic vesicles and the midbrain/hindbrain boundary. In contrast, XSPR-2 expression is found predominantly within the presumptive mesoderm during gastrulation. At tailbud and tadpole stages, XSPR-2 is expressed exclusively in the tip of the tail.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • Gene Expression Profiling
  • Gene Expression*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Sp1 Transcription Factor / genetics*
  • Transcription Factors / genetics*
  • Xenopus Proteins / genetics*
  • Xenopus laevis / embryology
  • Xenopus laevis / genetics*
  • Zinc Fingers*


  • DNA, Complementary
  • SP5 protein, Xenopus
  • Sp1 Transcription Factor
  • Transcription Factors
  • Xenopus Proteins
  • sp5l protein, Xenopus

Associated data

  • GENBANK/AY062263
  • GENBANK/AY062264