Diffusion tensor imaging in refractory epilepsy

Lancet. 2002 May 18;359(9319):1748-51. doi: 10.1016/S0140-6736(02)08615-4.


Diffusion tensor imaging is an imaging method that is sensitive to the molecular movement of water, which indicates cellular integrity and pathology. A patient with refractory epilepsy and normal conventional MRI was examined with diffusion tensor imaging. An area of abnormal diffusion in the right frontal lobe was identified and surgically resected. The patient had a good clinical outcome. Histopathological examination of the resected tissue showed gliosis. Our findings may affect the investigation of similar patients, and provide histopathological confirmation of diffusion abnormalities.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Electroencephalography
  • Epilepsy / diagnosis
  • Epilepsy / pathology*
  • Epilepsy / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Postoperative Period