Cryosurgery - a review of recent advances and current issues

Cryo Letters. 2002 Mar-Apr;23(2):69-78.


Advances in cryosurgery since 1990 were initiated by the development of improved cryosurgical equipment and by the availability of intraoperative ultrasound to monitor the tissue-freezing process. Interest in research on the effects of freezing on tissue and on new clinical applications was then stimulated. The research led to a better understanding of the mechanisms of cryogenic injury, including cell death by apoptosis, which has emerged as a potential key to the use of adjunctive chemotherapy in the treatment of cancer. Optimization of cryosurgical technique will also improve clinical results.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arrhythmias, Cardiac / surgery
  • Cryosurgery* / instrumentation
  • Cryosurgery* / methods
  • Humans
  • Neoplasms / surgery