Linkage of essential hypertension to chromosome 18q

Hypertension. 2002 Jun;39(6):1044-9. doi: 10.1161/01.hyp.0000018580.24644.18.


We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.

MeSH terms

  • Adult
  • Aged
  • Chromosomes, Human, Pair 18*
  • Family Health
  • Female
  • Genetic Linkage*
  • Genetic Predisposition to Disease*
  • Genome, Human
  • Humans
  • Hypertension / diagnosis
  • Hypertension / genetics*
  • Iceland
  • Male
  • Middle Aged