The effect of housing and gender on preference for morphine-sucrose solutions in rats

Psychopharmacology (Berl). 1979;66(1):87-91. doi: 10.1007/BF00431995.


To determine whether opiate consumption is affected by laboratory housing, individually caged and colony rats were given a choice between water and progressively more palatable morphine-sucrose solutions. The isolated rats drank significantly more of the opiate solution, and females drank significantly more than males. In the experimental phase during which morphine-sucrose solution consumption was greatest, the isolated females drank five times as much, and the isolated males sixteen times as much morphine (mg/kg) as the colony females and males respectively.

MeSH terms

  • Animals
  • Choice Behavior / drug effects*
  • Drinking Behavior / drug effects
  • Female
  • Housing, Animal*
  • Male
  • Morphine / pharmacology*
  • Rats
  • Sex Factors
  • Social Isolation
  • Sucrose


  • Sucrose
  • Morphine