Abstract
Esters of three types of silylated alpha-amino acids have been prepared from appropriate zirconaaziridines. Slow addition (syringe pump) of the (R,R) carbonate of trans-stilbene gave metallacycles with the maximum possible diastereomeric excess (as determined by the diastereomeric excess produced by the Hoffmann test-the same reaction but with racemic carbonate). Methanolysis gave esters (RO(2)C)CH(R')(NHPh) (R' = Me(3)Si, Me(3)SiCH(2), and p-Me(3)SiC(6)H(4)) with the same optical purity at the alpha carbon.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Algorithms
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry*
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Catalysis
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Chemistry, Organic / methods*
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Chromatography, High Pressure Liquid
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Esters / chemistry*
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Furans / chemistry
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Kinetics
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Silicon / chemistry*
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Stereoisomerism
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Zirconium / chemistry
Substances
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Amino Acids
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Esters
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Furans
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Organometallic Compounds
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Zirconium
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Silicon