Reduced Expression of PTEN Correlates With Breast Cancer Progression

Hum Pathol. 2002 Apr;33(4):405-9. doi: 10.1053/hupa.2002.124721.

Abstract

PTEN is a tumor-suppressor gene with phosphatase activity that is mutated in a variety of cancers. We analyzed a series of 34 invasive and 18 in situ breast cancers with known molecular status of the PTEN genotype using immunohistochemistry. Reduced PTEN protein expression was seen in 38% of invasive cancers and in 11% of in situ cancers. The frequency of reduced expression was highest in stage II and III cancers. Reduced expression also correlated with aneuploidy. In addition, in tumors with both in situ and invasive components, expression within the ductal carcinoma in situ portion tended to reflect the expression pattern of the invasive component. These data suggest that PTEN expression is frequently reduced in advanced breast cancers.

MeSH terms

  • Aneuploidy
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Carcinoma in Situ / chemistry
  • Carcinoma in Situ / genetics
  • Carcinoma in Situ / pathology
  • Carcinoma, Intraductal, Noninfiltrating / chemistry
  • Carcinoma, Intraductal, Noninfiltrating / genetics
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Genotype
  • Humans
  • Immunohistochemistry
  • Loss of Heterozygosity
  • Neoplasm Staging
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases / analysis
  • Phosphoric Monoester Hydrolases / genetics*
  • Tumor Suppressor Proteins / analysis
  • Tumor Suppressor Proteins / genetics*

Substances

  • Tumor Suppressor Proteins
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human