Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria

Trans R Soc Trop Med Hyg. Mar-Apr 2002;96(2):199-201. doi: 10.1016/s0035-9203(02)90304-4.

Abstract

We conducted a 14-day study (during March-May 1998) to assess the efficacy of chloroquine and sulfadoxine-pyrimethamine (SP) for treating uncomplicated Plasmodium falciparum malaria in Uganda. Overall treatment failure rates were 43 (81.1%) of 53 chloroquine recipients and 16 (25.0%) of 64 SP patients. Strategies to improve the life-span of standard and affordable anti-malarial drugs are needed.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / therapeutic use*
  • Child, Preschool
  • Chloroquine / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Infant, Newborn
  • Malaria, Falciparum / drug therapy*
  • Male
  • Pyrimethamine / therapeutic use*
  • Sulfadoxine / therapeutic use*
  • Treatment Outcome

Substances

  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Chloroquine
  • Pyrimethamine