Gestational trophoblastic disease

Curr Treat Options Oncol. 2000 Jun;1(2):169-75. doi: 10.1007/s11864-000-0062-5.


Patients diagnosed with molar pregnancy are treated by either suction curettage or hysterectomy, depending on their desire to preserve fertility. We use single-agent chemotherapy, preferably methotrexate, to treat low- or moderate-risk persistent trophoblastic tumors. High-risk patients who have metastatic disease are treated primarily with combination chemotherapy and, as indicated, adjuvant radiotherapy or surgery. We perform a hysterectomy in all cases of placental-site trophoblastic tumors; combination chemotherapy is used if there is evidence of metastatic disease.

Publication types

  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Female
  • Humans
  • Hysterectomy
  • Pregnancy
  • Prognosis
  • Radiotherapy, High-Energy
  • Remission Induction
  • Trophoblastic Neoplasms / therapy*
  • Uterine Neoplasms / therapy*


  • Antineoplastic Agents