Cranberry proanthocyanidins and the maintenance of urinary tract health

Crit Rev Food Sci Nutr. 2002;42(3 Suppl):273-8. doi: 10.1080/10408390209351915.

Abstract

One of the major health benefits attributed to the ingestion of cranberry juice is the maintenance of urinary tract health. Traditionally, the juice was thought to cause acidification of the urine resulting in a bacteriostatic effect. However, recent research has demonstrated that a bacterial antiadhesion mechanism is responsible. Proanthocyanidins with unique molecular structures have been isolated from cranberry fruit that exhibit potent bacterial antiadhesion activity. Little is known about the bioavailability and structure-activity relationships of cranberry proanthocyanidins. Data on how certain structural features of the molecules can influence bioactivity and bioavailability are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthocyanins / chemistry
  • Anthocyanins / pharmacology*
  • Anthocyanins / therapeutic use
  • Bacterial Adhesion / drug effects*
  • Beverages
  • Biological Availability
  • Escherichia coli / drug effects
  • Escherichia coli / pathogenicity
  • Escherichia coli / physiology
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / prevention & control
  • Food, Organic
  • Humans
  • Molecular Weight
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Proanthocyanidins*
  • Structure-Activity Relationship
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / prevention & control
  • Vaccinium macrocarpon* / chemistry

Substances

  • Anthocyanins
  • Plant Extracts
  • Proanthocyanidins
  • proanthocyanidin