Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts

Andrologia. 2002 Jun;34(3):177-9. doi: 10.1046/j.1439-0272.2002.00490.x.


Lepidium meyenii (Maca) is traditionally employed in the Andean region for its supposed properties in improving fertility. The aim of this study was to determine the effect of subacute oral administration of hexanic, methanolic and chloroformic extracts of Maca root on sexual performance in inexperienced male rats. The following sexual performance parameters were evaluated: 1st mount, 1st intromission, ejaculation and post-ejaculatory latencies, intercopulatory interval and copulatory efficacy. All the tested fractions significantly decreased intromission latency and intercopulatory interval and increased intromission frequency and copulatory efficacy (P < 0.05) as compared to controls. Hexanic and methanolic extracts were able to increase mount frequency (MF), while only hexanic fraction significantly improved mount latency (ML) (P=0.038). Globally, only the hexanic fraction significantly improved the majority of the sexual parameters measured. Sub-acute oral administration of hexanic Maca extract improved sexual performance parameters in sexually inexperienced male rats most effectively.

MeSH terms

  • Animals
  • Chloroform / chemistry*
  • Female
  • Hexanes / chemistry*
  • Lepidium / chemistry*
  • Male
  • Methanol / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Sexual Behavior, Animal / drug effects*


  • Hexanes
  • Plant Extracts
  • Chloroform
  • Methanol