Convergent extension: the molecular control of polarized cell movement during embryonic development

Dev Cell. 2002 Jun;2(6):695-706. doi: 10.1016/s1534-5807(02)00197-1.


During development, vertebrate embryos undergo dramatic changes in shape. The lengthening and narrowing of a field of cells, termed convergent extension, contributes to a variety of morphogenetic processes. Focusing on frogs and fish, we review the different cellular mechanisms and the well-conserved signaling pathways that underlie this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anura
  • Cell Communication
  • Cell Differentiation
  • Cell Movement / physiology*
  • Cell Polarity / physiology*
  • Cell Size
  • Embryo, Nonmammalian / physiology*
  • Fishes
  • Models, Biological
  • Morphogenesis
  • Xenopus