An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development

Dev Cell. 2002 Jun;2(6):807-17. doi: 10.1016/s1534-5807(02)00174-0.


Plants recognize many pathogens through the action of a diverse family of proteins called disease resistance (R) genes. The Arabidopsis R gene RPM1 encodes resistance to specific Pseudomonas syringae strains. We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and beta-catenin-mediated signaling in animals. Reduction of Arabidopsis TIP49a (AtTIP49a) mRNA levels results in measurable increases of two R-dependent responses without constitutively activating defense responses, suggesting that AtTIP49a can act as a negative regulator of at least some R functions. Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arabidopsis / embryology*
  • Arabidopsis / genetics
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Clone Cells
  • Conserved Sequence
  • DNA Helicases
  • Evolution, Molecular
  • Gene Deletion
  • Gene Expression Regulation
  • Genes, Plant
  • Immunity, Innate / genetics*
  • Plant Diseases / genetics*
  • Plant Proteins / metabolism
  • Pseudomonas / pathogenicity
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Recombinant Fusion Proteins / isolation & purification
  • Recombinant Fusion Proteins / metabolism
  • Suppression, Genetic


  • Arabidopsis Proteins
  • Carrier Proteins
  • Plant Proteins
  • RNA, Messenger
  • RPM1 protein, Arabidopsis
  • Recombinant Fusion Proteins
  • DNA Helicases
  • TIP49a protein, Arabidopsis