Review
doi: 10.1016/s0092-8674(02)00765-1.
PI 3-kinases and PTEN: how opposites chemoattract
Affiliations
- PMID: 12062096
- DOI: 10.1016/s0092-8674(02)00765-1
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Review
PI 3-kinases and PTEN: how opposites chemoattract
Cell.
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Free article
Abstract
Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.
Comment on
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Tumor suppressor PTEN mediates sensing of chemoattractant gradients.Cell. 2002 May 31;109(5):599-610. doi: 10.1016/s0092-8674(02)00745-6. Cell. 2002. PMID: 12062103
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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.Cell. 2002 May 31;109(5):611-23. doi: 10.1016/s0092-8674(02)00755-9. Cell. 2002. PMID: 12062104
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