At the center of eukaryotic life

Cell. 2002 May 31;109(5):545-8. doi: 10.1016/s0092-8674(02)00761-4.

Abstract

The ribosomal RNA genes encode the enzymatic scaffold of the ribosome and thereby perform perhaps the most basic of all housekeeping functions. However, recent data suggests that they might also control important aspects of cell behavior.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleolus / genetics*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism*
  • Gene Expression Regulation / genetics*
  • Gene Silencing / physiology
  • Genes / genetics*
  • Humans
  • Promoter Regions, Genetic / genetics
  • RNA Polymerase I / genetics
  • RNA, Ribosomal / biosynthesis
  • RNA, Ribosomal / genetics*
  • Transcription, Genetic / genetics*

Substances

  • RNA, Ribosomal
  • RNA Polymerase I