Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc

Cell. 2002 May 31;109(5):651-61. doi: 10.1016/s0092-8674(02)00744-4.

Abstract

A central issue in developmental biology is how the deployment of generic signaling proteins produces diverse specific outcomes. We show that Drosophila FGF is used, only in males, to recruit mesodermal cells expressing its receptor to become part of the genital imaginal disc. Male-specific deployment of FGF signaling is controlled by the sex determination regulatory gene doublesex. The recruited mesodermal cells become epithelial and differentiate into parts of the internal genitalia. Our results provide exceptions to two basic tenets of imaginal disc biology-that imaginal disc cells are derived from the embryonic ectoderm and belong to either an anterior or posterior compartment. The recruited mesodermal cells migrate into the disc late in development and are neither anterior nor posterior.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Compartmentation / genetics
  • Cell Differentiation / genetics*
  • Cell Lineage / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / growth & development*
  • Drosophila melanogaster / metabolism
  • Epithelium / growth & development
  • Epithelium / metabolism
  • Female
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / metabolism*
  • Gene Expression Regulation, Developmental / physiology
  • Genitalia, Male / cytology
  • Genitalia, Male / growth & development*
  • Genitalia, Male / metabolism
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Larva / cytology
  • Larva / growth & development
  • Larva / metabolism
  • Male
  • Mesoderm / cytology
  • Mesoderm / metabolism*
  • Protein-Tyrosine Kinases*
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism
  • Sex Characteristics
  • Sex Differentiation*
  • Signal Transduction / genetics*
  • Stem Cells / cytology
  • Stem Cells / metabolism

Substances

  • DNA-Binding Proteins
  • DSX protein, Drosophila
  • Drosophila Proteins
  • Insect Proteins
  • Receptors, Fibroblast Growth Factor
  • bnl protein, Drosophila
  • Fibroblast Growth Factors
  • BTL protein, Drosophila
  • Protein-Tyrosine Kinases