The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

Trends Cell Biol. 2002 May;12(5):205-9. doi: 10.1016/s0962-8924(02)02276-6.


The spindle checkpoint coordinates the cell biology of mitosis with cell-cycle progression. It ensures that sister-chromatid separation only takes place when all kinetochores have formed stable bipolar microtubule attachments. Here, we discuss recent advances in our understanding of what activates this checkpoint pathway, the molecular nature of the checkpoint signal and its mode of transmission, and how the checkpoint might be inactivated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase
  • Animals
  • Humans
  • Kinetics
  • Metaphase
  • Microtubules / metabolism*
  • Mitosis
  • Models, Biological
  • Signal Transduction
  • Spindle Apparatus*
  • Xenopus