Joining the cell survival squad: an emerging role for protein kinase CK2

Trends Cell Biol. 2002 May;12(5):226-30. doi: 10.1016/s0962-8924(02)02279-1.

Abstract

Protein kinase CK2 (formerly known as casein kinase 2) is a serine/threonine protein kinase whose functions have been under investigation for over three decades, leading to the recognition that it interacts with several signaling pathways. Recent demonstrations of signal-mediated dynamic localization of CK2 and the identification of new signaling targets for it have converged to indicate an unexpected function for this protein kinase: cell survival. Here, we summarize our emerging knowledge about how CK2 might participate in the transduction of survival signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / enzymology
  • Casein Kinase II
  • Cell Division
  • Cell Survival
  • Crystallography, X-Ray
  • Humans
  • Models, Biological
  • Models, Molecular
  • Neoplasms / enzymology
  • Protein-Serine-Threonine Kinases / chemistry*
  • Protein-Serine-Threonine Kinases / physiology*
  • Saccharomyces cerevisiae / enzymology
  • Signal Transduction

Substances

  • Casein Kinase II
  • Protein-Serine-Threonine Kinases