Application of gene expression profiling to cardiovascular disease

Cardiovasc Res. 2002 Apr;54(1):16-24. doi: 10.1016/s0008-6363(01)00516-8.


The number of cardiovascular publications featuring gene expression profiling technologies is growing rapidly. This article introduces four profiling techniques; serial analysis of gene expression, differential display, subtractive hybridisation and DNA microarrays. Illustrations of their application towards cardiovascular research are given and their potential for gene discovery and improving our understanding of gene function is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / embryology
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / genetics*
  • Cells, Cultured
  • Gene Expression Profiling*
  • Humans
  • Image Processing, Computer-Assisted
  • Models, Animal
  • Myocardium / metabolism
  • Oligonucleotide Array Sequence Analysis*
  • Reverse Transcriptase Polymerase Chain Reaction