Granulomatous myopathy: its relationship to sarcoidosis and polymyositis

J Neurol Neurosurg Psychiatry. 1975 Nov;38(11):1090-9. doi: 10.1136/jnnp.38.11.1090.


In three cases of generalized muscle weakness, muscle biopsy revealed well-defined, non-caseating epithelioid granulomata with giant cells. In one of these patients there was, in addition, a high serum CPK and histological evidence of widespread muscle cell degeneration and regeneration, apparently unrelated to the granulomatous process. In a re-examination of the histopathology of these cases, using biopsy material from a fourth case of proven sarcoidosis as a standard, it was concluded that there are no special features of the granulomatous/giant cell process which permit the separation of the case of presumed polymyositis. However, it appeared that granulomata per se do not exert a significant ill effect on surrounding muscle cells, and that evidence of widespread degeneration of muscle cells is the important point of distinction.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Creatine Kinase / blood
  • Female
  • Granuloma / diagnosis
  • Granuloma / drug therapy
  • Granuloma / pathology*
  • Humans
  • Male
  • Muscles / pathology*
  • Muscular Diseases / diagnosis
  • Muscular Diseases / drug therapy
  • Muscular Diseases / pathology*
  • Myositis / pathology
  • Prednisone / therapeutic use
  • Sarcoidosis / pathology
  • Syndrome


  • Creatine Kinase
  • Prednisone