Tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity

J Natl Cancer Inst. 1975 Nov;55(5):1233-6. doi: 10.1093/jnci/55.5.1233.

Abstract

Lymphokines such as migration inhibitory factor and type II interferon were released into the circulation of tuberculin-sensitive mice after iv injection of old tuberculin. Daily administration of such sera into the tumor sites of mice given implants of sarcoma MC-36 markedly suppressed tumor growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Hypersensitivity, Delayed / immunology
  • Lymphokines / therapeutic use*
  • Mice
  • Mice, Inbred C3H
  • Monocytes / cytology
  • Neoplasm Transplantation
  • Sarcoma, Experimental / immunology
  • Sarcoma, Experimental / pathology
  • Sarcoma, Experimental / therapy*

Substances

  • Lymphokines