Inhibitory effect of sodium ascorbate on ethylurea and sodium nitrite carcinogensis and negative findings in progeny after intestinal inoculation of precursors into pregnant hamsters

J Natl Cancer Inst. 1975 Dec;55(6):1389-94. doi: 10.1093/jnci/55.6.1389.

Abstract

To assess their carcinogenic effects, the ethylnitrosourea (ENU) precursors, ethylurea and sodium nitrite, [were administered to pregnant hamsters as a single intragastic] dose on day 15 of gestation, or introduced into the cecum on day 14. Since sodium ascorbate (NaASC) inhibits the biosynthesis of nitrosamides, identical doses of the precursors were given concomitantly with NaASC. Progeny of mothers treater intragastrically developed significant incidences of neurogenic tumors of the peripheral nervous system, with a predominance in females. The concurrent administration of NaASC with ENU precursors prevented carcinogenic effects in the progency, whereas the simultaneous inoculation of the precursors into the cecum produced no carcinogenic effects in the offspring.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Ascorbic Acid / pharmacology*
  • Astrocytoma / chemically induced
  • Brain Neoplasms / chemically induced
  • Cecum
  • Cricetinae
  • Ethylnitrosourea / biosynthesis
  • Female
  • Intubation, Gastrointestinal
  • Male
  • Maternal-Fetal Exchange*
  • Neoplasms, Experimental / chemically induced
  • Nitrites / antagonists & inhibitors*
  • Nitroso Compounds
  • Peripheral Nervous System Neoplasms / chemically induced
  • Pons
  • Pregnancy
  • Sex Factors
  • Urea / analogs & derivatives*
  • Urea / antagonists & inhibitors
  • Urea / toxicity

Substances

  • Nitrites
  • Nitroso Compounds
  • Urea
  • Ethylnitrosourea
  • Ascorbic Acid