The nuclear envelope, lamins and nuclear assembly

Curr Opin Cell Biol. 2002 Jun;14(3):357-64. doi: 10.1016/s0955-0674(02)00329-0.


The nuclear lamina is composed of both A- and B-type lamins and lamin-binding proteins. Many lamin-binding proteins are integral proteins of the inner nuclear membrane. Lamins and inner nuclear membrane proteins are important for a variety of cell functions, including nuclear assembly, replication, transcription, and nuclear integrity. Recent advances in the field in the past year include the identification of a family of spectrin-repeat-containing inner nuclear membrane proteins and other novel inner-membrane proteins, and the discovery of a nuclear membrane fusion complex. There is also growing evidence that A- and B-type lamins and their binding partners have distinct roles during nuclear assembly and interphase.

Publication types

  • Review

MeSH terms

  • A Kinase Anchor Proteins
  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / metabolism
  • Gene Expression Regulation
  • Genetic Diseases, Inborn / etiology
  • Humans
  • Lamins / physiology*
  • Membrane Fusion
  • Membrane Proteins / metabolism
  • Nuclear Envelope / metabolism*
  • Nuclear Pore / metabolism
  • Nuclear Proteins / metabolism
  • Plants / genetics


  • A Kinase Anchor Proteins
  • AKAP1 protein, human
  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Lamins
  • Membrane Proteins
  • Nuclear Proteins