Bi-orienting chromosomes on the mitotic spindle

Curr Opin Cell Biol. 2002 Jun;14(3):365-71. doi: 10.1016/s0955-0674(02)00328-9.


For the proper segregation of sister chromatids before cell division, each sister kinetochore must attach to microtubules that extend to opposite spindle poles. This process is called bipolar microtubule attachment or chromosome bi-orientation. The mechanism for chromosome bi-orientation lies at the heart of chromosome segregation, but is still poorly understood. Recent studies suggest that cells can promote bi-orientation by re-orienting kinetochore-spindle pole connections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aurora Kinases
  • Chromatin / physiology
  • Chromosomal Proteins, Non-Histone / physiology
  • Chromosome Segregation*
  • Chromosomes / genetics*
  • DNA-Binding Proteins / physiology
  • Kinetochores / physiology
  • Macromolecular Substances
  • Models, Genetic
  • Nuclear Proteins / physiology
  • Protein Serine-Threonine Kinases / physiology
  • Saccharomyces cerevisiae Proteins*
  • Sister Chromatid Exchange
  • Spindle Apparatus / physiology*


  • CSE4 protein, S cerevisiae
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Aurora Kinases
  • Protein Serine-Threonine Kinases