Salmon calcitonin - a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents

J Physiol. 2002 Jun 15;541(Pt 3):1041-8. doi: 10.1113/jphysiol.2002.018671.

Abstract

To compare the anorectic effectiveness of leptin and the amylin analogue salmon calcitonin (sCT), rodents were treated on 1 day with subcutaneous injections. In chow-fed C57Bl/6J mice, leptin and sCT reduced energy intake and acted additively. After C57Bl/6J mice had become leptin-resistant on being fed chocolate as a palatable high-caloric supplement to chow, their sCT-induced decrease in energy intake was more pronounced than in chow-fed mice with differential changes in the intake of chocolate (strong reduction) and chow (slight increase). Dose-response relationships for sCT-induced reductions in energy intake were analysed in chow-fed C57Bl/6J mice and two obese strains, ob/ob mice and melanocortin-4 receptor knockout (MC4-r-KO) mice, as well as in wild-type and fatty (fa/fa) rats. Compared to C57Bl/6J mice, reduction in food intake induced by sCT was attenuated in MC4-r-KO mice, and nearly absent in ob/ob mice, over the dose range investigated. Compared to C57Bl/6J mice, wild-type rats responded more sensitively to sCT and its efficiency was only slightly reduced in fatty (fa/fa) rats. Thus, while genetically induced failures of leptin signalling reduce the action of sCT, it effectively inhibits the intake of a palatable, high fat-high sugar diet even in states of diet-induced obesity with functional leptin resistance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Mass Index
  • Calcitonin / pharmacology*
  • Diet
  • Eating / drug effects*
  • Energy Intake / drug effects
  • Female
  • Insulin / blood
  • Leptin / deficiency
  • Leptin / genetics
  • Leptin / physiology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Obese
  • Rats
  • Rats, Inbred Strains
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin / deficiency
  • Receptors, Corticotropin / genetics
  • Receptors, Leptin
  • Signal Transduction / physiology*

Substances

  • Insulin
  • Leptin
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin
  • Receptors, Leptin
  • leptin receptor, mouse
  • salmon calcitonin
  • Calcitonin