[Moyamoya and Down syndrome: study conducted by meta-analysis]

Arq Neuropsiquiatr. 2002 Jun;60(2-A):274-80.
[Article in Portuguese]


We present a clinic-epidemiological study of two patients and meta-analysis (period 1977-2000 ) of the co-morbidity of the Down syndrome (DS) and moyamoya syndrome (MMS). Among the 42 patients listed in this survey, meta-analysis permitted to find the highest number of publications by researchers from Japan and United States, followed by Brazil and Italy; prevalence of cerebrovascular disease in suckling and pre school children; first symptomatology was hemiparesis (78.6%), speech disorders (26.2%); ischemic infarction (76.2%); recurring ischemic episodes (62%); bilateral impairment (83.3%). This analysis led to the conclusion that in the clinic-neurological investigation of DS patients with acute hemiparesis episodes, MMS should be included as the most probable diagnosis.

Publication types

  • Case Reports
  • Meta-Analysis
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Cerebral Angiography
  • Child
  • Child, Preschool
  • Down Syndrome / complications*
  • Female
  • Humans
  • Magnetic Resonance Angiography
  • Male
  • Moyamoya Disease / complications*
  • Moyamoya Disease / diagnosis
  • Stroke / complications
  • Stroke / diagnostic imaging
  • Ultrasonography