Low, but Not High, Doses of Melatonin Entrained a Free-Running Blind Person With a Long Circadian Period

Chronobiol Int. 2002 May;19(3):649-58. doi: 10.1081/cbi-120004546.

Abstract

In a previous report, we were unable to entrain one out of seven totally blind people with free-running endogenous melatonin rhythms to 10 mg of exogenous melatonin. This person had the longest circadian period (24.9 h) of the group. We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Blindness / complications*
  • Blindness / physiopathology
  • Circadian Rhythm / drug effects*
  • Circadian Rhythm / physiology
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Melatonin / administration & dosage*
  • Middle Aged
  • Sleep Disorders, Circadian Rhythm / drug therapy*
  • Sleep Disorders, Circadian Rhythm / etiology*
  • Sleep Disorders, Circadian Rhythm / physiopathology

Substances

  • Melatonin