Effect of cod liver oil on symptoms of rheumatoid arthritis

Adv Ther. Mar-Apr 2002;19(2):101-7. doi: 10.1007/BF02850059.


In this pilot study, 43 patients with rheumatoid arthritis ingested 1 g of cod liver oil (one capsule) daily for 3 months. Decreases occurred in morning stiffness (52.4%; P<10(-3)), painful (42.7%) and swollen (40%) joints (P= 10(-3) each), and pain intensity (67.5%). Ratings of "good" or "very good" were awarded by 68% of the patients for efficacy and by 95% for tolerability. Eleven patients reported nonsevere adverse effects that in 3 cases may have been related to the study preparation. Cod liver oil can be recommended for the treatment of rheumatoid arthritis.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / drug therapy*
  • Cod Liver Oil / administration & dosage
  • Cod Liver Oil / therapeutic use*
  • Dietary Supplements
  • Drug Administration Schedule
  • Female
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Time Factors
  • Treatment Outcome


  • Cod Liver Oil