Abstract
Since its discovery 2 decades ago, potent effects of corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cardiovascular System / drug effects
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Cardiovascular System / physiopathology*
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Carrier Proteins / metabolism
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Corticotropin-Releasing Hormone / pharmacology
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Corticotropin-Releasing Hormone / physiology
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Humans
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Molecular Sequence Data
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Receptors, Corticotropin-Releasing Hormone / chemistry
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Receptors, Corticotropin-Releasing Hormone / genetics
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Receptors, Corticotropin-Releasing Hormone / metabolism*
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Sequence Alignment
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Stress, Psychological / physiopathology*
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Urocortins
Substances
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CRF receptor type 2
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Carrier Proteins
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Receptors, Corticotropin-Releasing Hormone
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Urocortins
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Corticotropin-Releasing Hormone