Vanilloid and TRP channels: a family of lipid-gated cation channels

Neuropharmacology. 2002 Jun;42(7):873-88. doi: 10.1016/s0028-3908(02)00047-3.


The emergence of the TRP (C) and vanilloid (TRPV) receptor family of Ca(2+) permeable channels has started to provide molecular focus to a linked group of ion channels whose common feature is activation primarily by intracellular ligands. These channels have a central role in Ca(2+) homeostasis in virtually all cells and in particular those that lack voltage-gated Ca(2+) channels. We will discuss recent work that is more precisely defining both molecular form and physiological function of this important group of Ca(2+) permeable channels with particular focus on the intracellular ligands that gate and modulate channel activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Channels / genetics
  • Calcium Channels / physiology*
  • Humans
  • Ion Channel Gating / physiology*
  • Lipids / physiology*
  • Receptors, Drug / genetics
  • Receptors, Drug / physiology*
  • TRPC Cation Channels
  • Transcription, Genetic


  • Calcium Channels
  • Lipids
  • Receptors, Drug
  • TRPC Cation Channels