Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1

Antimicrob Agents Chemother. 2002 Jul;46(7):2254-6. doi: 10.1128/AAC.46.7.2254-2256.2002.


We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Drug Resistance, Viral
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / drug effects*
  • Humans
  • Lamivudine / pharmacology*
  • Mutation*
  • Virus Replication / drug effects
  • Zidovudine / pharmacology*


  • Anti-HIV Agents
  • Lamivudine
  • Zidovudine
  • HIV Reverse Transcriptase