Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions

Virchows Arch. 2002 Jun;440(6):594-7. doi: 10.1007/s00428-002-0616-y. Epub 2002 Feb 21.

Abstract

The expression of Cox-2 protein was studied by immunohistochemistry in normal oral mucosa and in mucosa with various lesions of oral leukoplakia, including hyperplasia and dysplasia of squamous epithelium and frank invasive squamous carcinoma. A gradient of Cox-2 staining was found: the expression of Cox-2 was lowest in normal epithelium, somewhat increased in hyperplastic epithelium, further increased in dysplastic epithelium, and highest in invasive squamous cell carcinomas. The presence of Cox-2 in squamous cell carcinomas of the oral mucosa and its precursor lesions indicate that Cox-2 could participate in the carcinogenic process of these oral malignancies.

MeSH terms

  • Carcinoma, Squamous Cell / enzymology*
  • Carcinoma, Squamous Cell / etiology
  • Cyclooxygenase 2
  • Humans
  • Immunohistochemistry
  • Isoenzymes / biosynthesis*
  • Membrane Proteins
  • Mouth Mucosa / enzymology
  • Mouth Mucosa / pathology
  • Precancerous Conditions / enzymology*
  • Precancerous Conditions / pathology
  • Prostaglandin-Endoperoxide Synthases / biosynthesis*
  • Tongue Neoplasms / enzymology*
  • Tongue Neoplasms / etiology
  • Up-Regulation

Substances

  • Isoenzymes
  • Membrane Proteins
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases