CD83 on dendritic cells: more than just a marker for maturation

Trends Immunol. 2002 Jun;23(6):273-5. doi: 10.1016/s1471-4906(02)02214-7.


CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evidence that CD83 might also be important for DC biology. Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Immunoglobulins / chemistry
  • Immunoglobulins / physiology*
  • Lymphocyte Activation
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Knockout
  • Peptide Initiation Factors / metabolism
  • Protein Structure, Tertiary
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins*
  • Recombinant Fusion Proteins / physiology
  • Simplexvirus / physiology
  • Solubility
  • T-Lymphocyte Subsets / immunology*


  • Antigens, CD
  • CD83 antigen
  • Immunoglobulins
  • Membrane Glycoproteins
  • Peptide Initiation Factors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Recombinant Fusion Proteins
  • eukaryotic translation initiation factor 5A