Biotechnological production of 2-phenylethanol

Appl Microbiol Biotechnol. 2002 Jun;59(1):1-8. doi: 10.1007/s00253-002-0992-x. Epub 2002 Apr 20.


2-Phenylethanol (2-PE) is an important flavour and fragrance compound with a rose-like odour. Most of the world's annual production of several thousand tons is synthesised by chemical means but, due to increasing demand for natural flavours, alternative production methods are being sought. Harnessing the Ehrlich pathway of yeasts by bioconversion of L-phenylalanine to 2-PE could be an option, but in situ product removal is necessary due to product inhibition. This review describes the microbial production of 2-PE, and also summarizes the chemical syntheses and the market situation.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Bacteria / metabolism
  • Biotechnology / methods*
  • Chemical Industry / methods
  • Fermentation
  • Flavoring Agents / metabolism*
  • Fungi / metabolism
  • Phenylethyl Alcohol / chemical synthesis
  • Phenylethyl Alcohol / metabolism*


  • Flavoring Agents
  • Phenylethyl Alcohol