Seroprevalence of Antibodies to Hepatitis A and E Viruses in Pediatric Age Groups in Turkey

Acta Microbiol Immunol Hung. 2002;49(1):93-7. doi: 10.1556/AMicr.49.2002.1.9.


Hepatitis A and hepatitis E are enteric transmitted viral diseases occurring in epidemic and sporadic forms especially in developing countries. Previous studies in Turkey showed that most residents are infected with HAV by the second decade of life. Since HEV is generally transmitted by the same route as HAV we conducted a community-based seroprevalence study for HAV and HEV infection in Ahatli area in Antalya, Turkey where socioeconomic conditions are low. Anti-HAV total immunoglobulin was tested by using a microparticle EIA (Axsym-Abbott Lab). Anti-HEV IgG was assayed by a micro ELISA method (Genelabs-Singapore). Of the 338 sera tested, 112 (33.1%) were positive for anti-HAV total antibody. Anti-HEV IgG was detected in three (0.89%) of the serum samples. Seropositivity rates of HAV in preschool and school children were 19.9% and 43.9% respectively (p < 0.001). No antibody to HEV was detected in preschool children, while the prevalence of anti-HEV IgG was 1.6% in children attending school. Our data showed that seroprevalence of anti-HAV is high among children samples but HEV infection appears to be relatively rare in pediatric age groups.

MeSH terms

  • Child
  • Child, Preschool
  • Hepatitis A / epidemiology*
  • Hepatitis A / virology
  • Hepatitis A Antibodies / blood
  • Hepatitis A Virus, Human / immunology*
  • Hepatitis Antibodies / blood*
  • Hepatitis E / epidemiology*
  • Hepatitis E / virology
  • Hepatitis E virus / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Infant
  • Prevalence
  • Seroepidemiologic Studies
  • Turkey / epidemiology


  • Hepatitis A Antibodies
  • Hepatitis Antibodies
  • Immunoglobulin G