Downstream targets of let-60 Ras in Caenorhabditis elegans

Dev Biol. 2002 Jul 1;247(1):127-36. doi: 10.1006/dbio.2002.0692.


In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins*
  • Gene Expression Regulation, Developmental*
  • Helminth Proteins / genetics
  • Oligonucleotide Array Sequence Analysis
  • Signal Transduction / genetics
  • ras Proteins / genetics*


  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • let-60 protein, C elegans
  • ras Proteins