Total synthesis of (+/-)-O-methyl PD 116740

Org Lett. 2002 Jun 27;4(13):2237-9. doi: 10.1021/ol026104r.

Abstract

[reaction: see text] Condensation of the phthalide sulfide with an ortho-quinone monoketal was employed as a key step in the first total synthesis of a derivative of (+/-)-PD 116740.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Benz(a)Anthracenes / chemical synthesis*
  • Benzofurans / chemistry
  • Hydroxylation
  • Quinones / chemistry
  • Stereoisomerism
  • Sulfides / chemistry

Substances

  • Benz(a)Anthracenes
  • Benzofurans
  • PD 116740
  • Quinones
  • Sulfides
  • phthalide